In vitro characterization of [ 18F]-florbetaben, an Aβ imaging radiotracer

MT Fodero-Tavoletti; D Brockschnieder; VL Villemagne; L Martin; AR Connor; A Thiele; M Berndt; CA McLean; S Krause; CC Rowe; CL Masters; L Dinkelborg; T Dyrks; R Cappai

Journal article

In vitro characterization of [ 18F]-florbetaben, an Aβ imaging radiotracer

MT Fodero-Tavoletti, D Brockschnieder, VL Villemagne, L Martin, AR Connor, A Thiele, M Berndt, CA McLean, S Krause, CC Rowe, CL Masters, L Dinkelborg, T Dyrks, R Cappai

Nuclear Medicine and Biology | Published : 2012

DOI: 10.1016/j.nucmedbio.2012.03.001

Abstract

Purpose: Amyloid-β (Aβ) plaques are a major pathological hallmark of Alzheimer's disease (AD). The noninvasive detection of Aβ plaques may increase the accuracy of clinical diagnosis as well as monitor therapeutic interventions. While [ 11C]-PiB is the most widely used Aβ positron emission tomography (PET) radiotracer, due to the short half-life of 11C (20min), its application is limited to centers with an on-site cyclotron and 11C radiochemistry expertise. Therefore, novel [ 18F] (half-life 110min)-labeled Aβ PET tracers have been developed. We have demonstrated that [ 18F]-florbetaben-PET can differentiate individuals diagnosed with AD from healthy elderly, Parkinson's disease and frontote..

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University of Melbourne Researchers

Victor Villemagne Author

Catriona McLean Author

Christopher Rowe Author

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Grants

Awarded by Bayer HealthCare

Funding Acknowledgements

This work was supported, in part, by Bayer HealthCare Pharmaceuticals and the National Health and Medical Research Council of Australia #509166. We thank Fairlie Hinton and Geoff Pavey from the Victorian Brain Bank Network, Australia, for sourcing and preparation of the human brain tissue. We thank Manuela Brand and Claudia Kamfenkel for excellent experimental support. M.F-T. is an Alzheimer's Australia Research Viertel Fellowship recipient. R.C. is an NHMRC Senior Research Fellow.